Article
Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology - 1 Jun 2006
Roest Mark, Rodenburg Jessica, Wiegman Albert, Kastelein John J P, Voorbij Hieronymus A M
Abstract excerpt
BACKGROUND: Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease. METHOD: We have studied the contribution of PON-1 and PON-2 single nucleotide polymorphisms (SNP; L55M, Q192R and T-107C, S311C) to the intima-media thickness of the common carotid artery in a population of children with classic familial hypercholesterolaemia. RESULTS: The L-variant of...
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