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Article

Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis.

Srpski arhiv za celokupno lekarstvo - 1 Jan 2000

Grubisa Ivana, Otasević Petar, Dimković Nada, Nedeljković Ivana, Toljić Bosko, Vucinić Nada

Abstract excerpt

INTRODUCTION: Paraoxonase 1 (PON1) is a multifunctional enzyme associated with high-density lipoprotein particles (HDL). It is a cellular antioxidant that hydrolyses oxidized macromolecules, especially low-density lipoproteins (ox-LDL). Because increased oxidative stress is believed to play a crucial role in the initiation and propagation of atherosclerosis, coding (Q192R and L55M) and promoter (C(-107)T) region...

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Identifiers

PMID: 24364225
DOI: 10.2298/sarh1310629g

Genes

PON1

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Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis.PMID 24364225Read ↗

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