Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.

doi:10.2147/VHRM.S165173

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance.

Vascular health and risk management - 1 Jan 2018

Shunmoogam Nelusha, Naidoo Poobalan, Chilton Robert

Abstract excerpt

Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated to play a role in several human diseases including diabetes mellitus and atherosclerosis. Low PON1 activity has been associated with increased risk of major cardiovascular events, therefore a variety of studies have been conducted to establish the cardioprotective properties and clinical relevance of PON1. The major aim of...

Topics

Animals
Aryldialkylphosphatase
Cardiovascular Diseases
Genetic Predisposition to Disease
Humans
Phenotype
Polymorphism, Genetic
Protein Conformation
Risk Assessment
Risk Factors
Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 29950852
DOI: 10.2147/VHRM.S165173
PMCID: PMC6014389

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics