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Article

Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2003

Senoo Makoto, Wang Lili, Suzuki Daisuke, Takeda Naoki, Shinkai Yoichi, Habu Sonoko

Abstract excerpt

Seventy percent of the murine TCRbeta locus (475 kb) was deleted to generate a large deleted TCRbeta (beta(LD)) allele to investigate a possible linkage between germline transcription, recombination frequency, and allelic exclusion of the TCR Vbeta genes. In these beta(LD/LD) mice, the TCRbeta gene locus contained only four Vbeta genes at the 5' side of the locus, and consequently, the Vbeta10 gene was located in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12847251
DOI: 10.4049/jimmunol.171.2.829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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