Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibship data.

Abstract excerpt

Sibships are commonly used in genetic dissection of complex diseases, particularly for late-onset diseases. Haplotype-based association studies have been advocated as powerful tools for fine mapping and positional cloning of complex disease genes. Existing methods for haplotype inference using data from relatives were originally developed for pedigree data. In this study, we proposed a new statistical method for...

Topics

• Algorithms
• Apolipoproteins E
• Computer Simulation
• Data Interpretation, Statistical
• Gene Frequency
• Genetics, Population
• Haplotypes
• Humans
• Likelihood Functions
• Models, Genetic
• Polymorphism, Single Nucleotide