Estimating haplotype relative risks in complex disease from unphased SNPs data in families using a likelihood adjusted for ascertainment.

doi:10.1002/gepi.20178

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Article

Estimating haplotype relative risks in complex disease from unphased SNPs data in families using a likelihood adjusted for ascertainment.

Genetic epidemiology - 1 Dec 2006

Carayol J, Philippi A, Tores F

Abstract excerpt

The understanding of complex diseases and insights to improve their medical management may be achieved through the deduction of how specific haplotypes may play a joint effect to change relative risk information. In this paper we describe an ascertainment adjusted likelihood-based method to estimate haplotype relative risks using pooled family data coming from association and/or linkage studies that were used to...

Topics

Algorithms
Family Health
Gene Frequency
Genetic Diseases, Inborn
Genotype
Haplotypes
Homozygote
Humans
Likelihood Functions
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Retrospective Studies
Risk
Software
Stochastic Processes

Source

Open in PubMed

Identifiers

PMID: 16917928
DOI: 10.1002/gepi.20178

Provenance

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