Estimation and testing of genotype and haplotype effects in case-control studies: comparison of weighted regression and multiple imputation procedures.

Abstract excerpt

A popular approach for testing and estimating genotype and haplotype effects associated with a disease outcome is to conduct a population-based case/control study, in which haplotypes are not directly observed but may be inferred probabilistically from unphased genotype data. A variety of methods exist to analyse the resulting data while accounting for the uncertainty in haplotype assignment, but most focus on...

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