Exploiting gene-environment independence in haplotype-based inferences for population-based case-control studies with complex sampling.

Abstract excerpt

The use of complex sampling in population-based case-control studies is becoming more common. Although most single nucleotide polymorphism-based association studies with complex sampling account for the design complications, many of haplotype-based genetic association studies with complex sampling tend to ignore them when estimating haplotype frequencies, regression coefficients, or both. In this article, we...

Topics

• Algorithms
• Case-Control Studies
• Computer Simulation
• Gene-Environment Interaction
• Genetic Association Studies
• Haplotypes
• Humans
• Likelihood Functions
• Monte Carlo Method
• Polymorphism, Single Nucleotide
• Regression Analysis