Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease.

doi:10.4049/jimmunol.174.2.636

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Article

Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2005

Sinha Pratima, Clements Virginia K, Ostrand-Rosenberg Suzanne

Abstract excerpt

More than 60% of STAT6(-/-) mice immunologically reject spontaneous metastatic mammary carcinoma and survive indefinitely if their primary tumors are removed, whereas 95% of STAT6-competent BALB/c mice succumb to metastatic disease. BALB/c and STAT6-deficient mice with primary tumors have elevated levels of Gr1(+)CD11b(+) myeloid suppressor cells (MSCs), which inhibit T cell activation. After removal of primary...

Topics

Animals
Arginase
Cell Line
Cell Line, Tumor
Cytotoxicity, Immunologic
Female
Genetic Predisposition to Disease
Interferon-gamma
Lung Neoplasms
Macrophage Activation
Macrophages
Mammary Neoplasms, Experimental
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Knockout

Mice, Transgenic

Myeloid Cells

Nitric Oxide Synthase

Source

Open in PubMed

Identifiers

PMID: 15634881
DOI: 10.4049/jimmunol.174.2.636

Genes

STAT6
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.