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Article

Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Ramachandran Indu R, Martner Anna, Pisklakova Alexandra, Condamine Thomas, Chase Tess, Vogl Thomas, Roth Johannes, Gabrilovich Dmitry, Nefedova Yulia

Abstract excerpt

Myeloid-derived suppressor cells (MDSC) are one of the major factors limiting the immune response in cancer. However, their role in bone marrow (BM), the site of primary localization of multiple myeloma (MM), is poorly understood. In this study, we found a significant accumulation of CD11b(+)CD14(-)CD33(+) immunosuppressive MDSC in BM of patients with newly diagnosed MM. To assess the possible role of MDSC in MM,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23460744
DOI: 10.4049/jimmunol.1203373
PMCID: PMC3608837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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