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Article

IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors.

Journal for immunotherapy of cancer - 1 Apr 2021

Beyranvand Nejad Elham, Labrie Camilla, van Elsas Marit J, Kleinovink Jan Willem, Mittrücker Hans-Willi, Franken Kees L M C, Heink Sylvia, Korn Thomas, Arens Ramon, van Hall Thorbald, van der Burg Sjoerd H

Abstract excerpt

BACKGROUND: High serum interleukin (IL-6) levels may cause resistance to immunotherapy by modulation of myeloid cells in the tumor microenvironment. IL-6 signaling blockade is tested in cancer, but as this inflammatory cytokine has pleiotropic effects, this treatment is not always effective. METHODS: IL-6 and IL-6R blockade was applied in an IL-6-mediated immunotherapy-resistant TC-1 tumor model (TC-1.IL-6) and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33879600
DOI: 10.1136/jitc-2021-002460
PMCID: PMC8061866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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