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Article

Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Michel Anastasija, Schüler Andrea, Friedrich Pamela, Döner Fatma, Bopp Tobias, Radsak Markus, Hoffmann Markus, Relle Manfred, Distler Ute, Kuharev Jörg, Tenzer Stefan, Feyerabend Thorsten B, Rodewald Hans-Reimer, Schild Hansjörg, Schmitt Edgar, Becker Marc, Stassen Michael

Abstract excerpt

Mast cell-deficient Kit(W-sh) "sash" mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin. In this study, we demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/macrophage progenitors in...

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PMID: 23636054
DOI: 10.4049/jimmunol.1203355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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