Article
Tumor-specific CD4(+) suppressor T-cell clone capable of inhibiting rejection of syngeneic sarcoma in A/J mice.
International journal of cancer - 1 Sept 2000
Fu T, Shen Y, Fujimoto S
Abstract excerpt
Elimination of CD4(+) T cells by anti-CD4 antibody caused regression of a methylcholanthrene-induced S713a sarcoma growing in syngeneic A/J mice, and the tumor regression was essentially required for CD8(+) T cells. A CD4(+) T-cell clone, designated T595B1, was established to elucidate the characteristics of CD4(+) suppressor T cells. T595B1 expressed CD3, T-cell receptor (TCR)beta, TCR-Vbeta2, CD4, CD25, CD45RB,...
Topics
- Adoptive Transfer
- Animals
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Clone Cells
- Cytokines
- Epitopes, T-Lymphocyte
- Methylcholanthrene
- Mice