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Article

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Fielding Ceri A, McLoughlin Rachel M, McLeod Louise, Colmont Chantal S, Najdovska Meri, Grail Dianne, Ernst Matthias, Jones Simon A, Topley Nicholas, Jenkins Brendan J

Abstract excerpt

The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained population of mononuclear cells. IL-6, which signals via the common receptor subunit gp130, represents a crucial checkpoint regulator of neutrophil trafficking during the inflammatory response by orchestrating chemokine production and leukocyte apoptosis. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytokine Receptor gp130

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Source

Identifiers

PMID: 18641358
DOI: 10.4049/jimmunol.181.3.2189

Genes

STAT3
CXCL1
STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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