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CD49d Is a New Marker for Distinct Myeloid-Derived Suppressor Cell Subpopulations in Mice

5 Jun 2010

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) are a heterogenous population of cells that negatively regulate the immune response during tumor progression, inflammation, and infection. In this study, through gene-expression analysis, we have identified a new marker, CD49d, which is expressed exclusively on CD11b(+)Gr-1(dull/int.) MDSCs. We have characterized two subpopulations of MDSCs based on CD49d expression in two...

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PMID: 20525890
DOI: 10.4049/jimmunol.0903573

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