Article
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.
Blood - 15 Apr 2008
Movahedi Kiavash, Guilliams Martin, Van den Bossche Jan, Van den Bergh Rafael, Gysemans Conny, Beschin Alain, De Baetselier Patrick, Van Ginderachter Jo A
Abstract excerpt
The induction of CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. However, the exact nature and function of MDSCs remain elusive, especially because they constitute a heterogeneous population that has not yet been clearly defined. Here, we identified 2 distinct MDSC subfractions with clear morphologic, molecular, and functional differences. These...
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