Article
In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site.
European journal of immunology - 1 Mar 2011
Haverkamp Jessica M, Crist Scott A, Elzey Bennett D, Cimen Cansu, Ratliff Timothy L
Abstract excerpt
Current paradigms suggest that, despite the heterogeneity of myeloid-derived suppressor cells (MDSC), all Gr-1(+) CD11b(+) cells can exert suppressive function when exposed to inflammatory stimuli. In vitro evaluation shows that MDSC from multiple tissue sites have suppressive activity, and in vivo inhibition of MDSC enhances T-cell function; however, the relative capacity of MDSC present at localized...
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