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Article

The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.

Journal of neuro-oncology - 1 May 2011

Estrada-Bernal Adriana, Lawler Sean E, Nowicki Michal O, Ray Chaudhury Abhik, Van Brocklyn James R

Abstract excerpt

We have previously shown that high expression levels of the lipid kinase sphingosine kinase-1 (SphK1) correlate with poor survival of glioblastoma (GBM) patients. In this study we examined the regulation of SphK1 expression by epidermal growth factor receptor (EGFR) signaling in GBM cells. As the EGFR gene is often overexpressed and mutated in GBM, and EGFR has been shown to regulate SphK1 in some cell types, we...

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Source

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Identifiers

PMID: 20938717
DOI: 10.1007/s11060-010-0345-z
PMCID: PMC3085825

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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