Article
A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.
Oncotarget - 30 Mar 2015
Pitman Melissa R, Powell Jason A, Coolen Carl, Moretti Paul A B, Zebol Julia R, Pham Duyen H, Finnie John W, Don Anthony S, Ebert Lisa M, Bonder Claudine S, Gliddon Briony L, Pitson Stuart M
Abstract excerpt
The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer. Sphingosine 1-phosphate is a signaling molecule with anti-apoptotic, pro-proliferative and pro-angiogenic effects, while conversely, ceramide and sphingosine are pro-apoptotic. The sphingosine kinases (SKs) are key regulators of this sphingolipid rheostat, and...
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