Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.

Scientific reports - 18 Nov 2020

Xie Jing, Shao Yong, Liu Jin, Cui Meilan, Xiao Xiuxiao, Gong Jingbo, Xue Binghua, Zhang Qunwei, Hu Xianwen, Duan Haifeng

Abstract excerpt

Obesity and its associated metabolic disorders are increasingly impacting public health worldwide. Sphingosine kinase 1 (Sphk1) is a critical enzyme in sphingolipid metabolism that has been implicated in various metabolic syndromes. In this study, we developed a mouse model constitutively expressing pseudoacetylated mouse Sphk1 (QSPHK1) to study its role in regulating glucose and lipid metabolism. The results...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Glucose

Share to Glucose Intolerance

Share to Homeostasis

Share to Obesity

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Open in PubMed Open full text

Identifiers

PMID: 33208918
DOI: 10.1038/s41598-020-77096-w
PMCID: PMC7676274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.PMID 33208918Read ↗

Adipocyte sphingosine kinase 1 regulates histone modifiers to disrupt circadian functionSemantic proximity Read ↗

Impact of Nutrition on Sphingolipid‐Regulated Physiology: A ReviewSemantic proximity Read ↗

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.Semantic proximity Read ↗

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal CancerSemantic proximity Read ↗

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphomaSemantic proximity Read ↗

Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.Semantic proximity Read ↗

Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammationSemantic proximity Read ↗

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.Semantic proximity Read ↗

PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.Semantic proximity Read ↗

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström SyndromeSemantic proximity Read ↗

Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice.Semantic proximity Read ↗

Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to HepatosteatosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.