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Article

Molecular Targeting of Acid Ceramidase: Implications to Cancer Therapy

1 Aug 2008

Abstract excerpt

Increasingly recognized as bioactive molecules, sphingolipids have been studied in a variety of disease models. The impact of sphingolipids on cancer research facilitated the entry of sphingolipid analogues and enzyme modulators into clinical trials. Owing to its ability to regulate two bioactive sphingolipids, ceramide and sphingosine-1-phosphate, acid ceramidase (AC) emerges as an attractive target for drug...

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PMID: 18691012
DOI: 10.2174/138945008785132358

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