Molecular basis of agonicity and antagonicity in the androgen receptor studied by molecular dynamics simulations.

Abstract excerpt

Treatment of prostate cancer patients with antiandrogens is initially successful, though the therapy often becomes refractory over the time. This mechanism is not fully understood, but the presence of androgen receptor (AR) mutant forms which are activated by antiandrogens and other endogenous ligands, and overexpression of the receptor have been suggested. In an attempt to explain the molecular basis for...

Topics

• Androgen Receptor Antagonists
• Androgens
• Anilides
• Computer Simulation
• Ligands
• Models, Molecular
• Molecular Structure
• Mutation
• Nitriles
• Protein Binding
• Receptors, Androgen
• Steroids
• Tosyl Compounds