Article
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
Genes & development - 15 Mar 1996
Hammerschmidt M, Bitgood M J, McMahon A P
Abstract excerpt
Midline signaling by Hedgehog (Hh) family members has been implicated in patterning the vertebrate embryo. We have explored the potential regulatory role of cAMP-dependent protein kinase A (PKA) in these events. Zebrafish embryos injected with RNAs encoding Sonic hedgehog (Shh), Indian hedgehog (...
Topics
- Animals
- Central Nervous System
- Cloning, Molecular
- Cyclic AMP-Dependent Protein Kinases
- Embryonic Development
- Embryonic Induction
- Epistasis, Genetic
- Eye
- Gene Expression Regulation, Developmental
- Gene Transfer Techniques
- Hedgehog Proteins
- Mutation
- Phenotype
- Proteins
- RNA
- Signal Transduction
- Trans-Activators
- Zebrafish