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Article

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

Genes & development - 15 Mar 1996

Hammerschmidt M, Bitgood M J, McMahon A P

Abstract excerpt

Midline signaling by Hedgehog (Hh) family members has been implicated in patterning the vertebrate embryo. We have explored the potential regulatory role of cAMP-dependent protein kinase A (PKA) in these events. Zebrafish embryos injected with RNAs encoding Sonic hedgehog (Shh), Indian hedgehog (Ihh), or a dominant-negative regulatory subunit of PKA, PKI, have equivalent phenotypes. These include the expansion of...

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PMID: 8598293
DOI: 10.1101/gad.10.6.647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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