Article
Genetic bases of estrogen-induced pituitary tumorigenesis: identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains.
Genetics - 1 Apr 2005
Strecker Tracy E, Spady Thomas J, Schaffer Beverly S, Gould Karen A, Kaufman Amy E, Shen Fangchen, McLaughlin Mac T, Pennington Karen L, Meza Jane L, Shull James D
Abstract excerpt
Estrogens stimulate proliferation and enhance survival of the prolactin (PRL)-producing lactotroph of the anterior pituitary gland and induce development of PRL-producing pituitary tumors in certain inbred rat strains but not others. The goal of this study was to elucidate the genetic bases of estrogen-induced pituitary tumorigenesis in reciprocal intercrosses between the genetically related ACI and Copenhagen...
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