Article
Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility.
International journal of cancer - 15 Apr 2007
Stieber Daniel, Piessevaux Géraldine, Rivière Michèle, Laes Jean-François, Quan Xiaojiang, Szpirer Josiane, Szpirer Claude
Abstract excerpt
We previously mapped several quantitative trait loci (QTLs) controlling DMBA-induced mammary tumor development in female rats derived from a SPRD-Cu3 (susceptible strain) x WKY (resistant strain) cross. Two of these QTLs were assigned to chromosomes 5 and 18. In the present study, we generated and characterized congenic strains in which a segment of WKY chromosomes 5 or 18 was introduced in the SPRD-Cu3 genetic...
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