Article
Association of cellular and molecular responses in the rat mammary gland to 17β-estradiol with susceptibility to mammary cancer.
BMC cancer - 5 Dec 2013
Ding Lina, Zhao Yang, Warren Christopher L, Sullivan Ruth, Eliceiri Kevin W, Shull James D
Abstract excerpt
BACKGROUND: We are using ACI and BN rats, which differ markedly in their susceptibility to 17β-estradiol (E2)-induced mammary cancer, to identify genetic variants and environmental factors that determine mammary cancer susceptibility. The objective of this study was to characterize the cellular and molecular responses to E2 in the mammary glands of ACI and BN rats to identify qualitative and quantitative...
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