Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention.

doi:10.1152/physiolgenomics.00105.2017

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Article

Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention.

Physiological genomics - 1 Mar 2018

Shull James D, Dennison Kirsten L, Chack Aaron C, Trentham-Dietz Amy

Abstract excerpt

Numerous laboratory and epidemiologic studies strongly implicate endogenous and exogenous estrogens in the etiology of breast cancer. Data summarized herein suggest that the ACI rat model of 17β-estradiol (E2)-induced mammary cancer is unique among rodent models in the extent to which it faithfully reflects the etiology and biology of luminal types of breast cancer, which together constitute ~70% of all breast...

Topics

Animals
Breast Neoplasms
Carcinogenesis
Disease Models, Animal
Estradiol
Female
Genetic Predisposition to Disease
Humans
Mammary Neoplasms, Animal

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Identifiers

PMID: 29373076
DOI: 10.1152/physiolgenomics.00105.2017
PMCID: PMC5899232

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