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Article

Genetic identification of multiple loci that control breast cancer susceptibility in the rat.

Genetics - 1 May 1998

Shepel L A, Lan H, Haag J D, Brasic G M, Gheen M E, Simon J S, Hoff P, Newton M A, Gould M N

Abstract excerpt

We have used a rat model of induced mammary carcinomas in an effort to identify breast cancer susceptibility genes. Using genetic crosses between the carcinoma-resistant Copenhagen (COP) and carcinoma-sensitive Wistar-Furth rats, we have confirmed the identification of the Mcs1 locus that modulates tumor number. We have now also identified two additional loci, Mcs2 and Mcs3. These three loci map to chromosomes 2,...

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Identifiers

PMID: 9584103
DOI: 10.1093/genetics/149.1.289
PMCID: PMC1460127

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Genetic identification of multiple loci that control breast cancer susceptibility in the rat.PMID 9584103Read ↗

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