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Article

The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF.

The Biochemical journal - 1 May 2005

Virtanen Heidi, Yang Jianmin, Bespalov Maxim M, Hiltunen Jukka O, Leppänen Veli-Matti, Kalkkinen Nisse, Goldman Adrian, Saarma Mart, Runeberg-Roos Pia

Abstract excerpt

The GDNF (glial cell line-derived neurotrophic factor)-binding receptor GFRalpha1 (GDNF family receptor alpha1) is attached to the membrane by a GPI (glycosylphosphatidylinositol) anchor and consists of three cysteine-rich domains. The region corresponding to the second and third domains has been shown previously to participate in ligand binding, and to interact with the transmembrane tyrosine kinase receptor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 15610063
DOI: 10.1042/BJ20041257
PMCID: PMC1135013

Genes

GDNF
GPI
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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