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Article

Binding of GDNF and Neurturin to Human GDNF Family Receptor α 1 and 2

1 Sept 2000

Abstract excerpt

The members of the glial cell line-derived neurotrophic factor (GDNF) family signal via binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family receptors alpha (GFRalpha), and activation of cRET. We performed a detailed analysis of the binding of GDNF and neurturin to their receptors and investigated the influence of cRET on the binding affinities. We show that the rate of...

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PMID: 10829012
DOI: 10.1074/jbc.m000306200

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