Article
Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding.
The Journal of biological chemistry - 25 Mar 1992
Marsters S A, Frutkin A D, Simpson N J, Fendly B M, Ashkenazi A
Abstract excerpt
The extracellular portion of the type 1 (p55) and type 2 (p75) tumor necrosis factor (TNF) receptors contains a repetitive amino acid sequence pattern of four cysteine-rich domains (CRDs). This pattern is found also in several other cell surface proteins, including the p75 nerve growth factor receptor and the CD40, 4-1BB, OX40, Fas, and CD27 antigens. To investigate whether CRDs play a role in TNF binding, we...
Topics
- Antibodies, Monoclonal
- Base Sequence
- Cell Line
- Cysteine
- Genetic Variation
- Humans
- Kinetics
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Protein Sorting Signals
- Receptors, Cell Surface