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Article

Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.

Journal of molecular neuroscience : MN - 1 Jan 2013

Talebian Asghar, Robinson-Brookes Kim, MacDonald James I S, Meakin Susan O

Abstract excerpt

We previously demonstrated that the guanine nucleotide exchange factor, RasGrf1, binds nerve growth factor (NGF)-activated TrkA and facilitates neurotrophin-induced neurite outgrowth in PC12 cells. RasGrf1 can activate both Ras and Rac, via intrinsic Cdc25 and DH domains, respectively, suggesting that the activation of both could contribute to this process. Previous studies have assayed constitutive neurite...

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Identifiers

PMID: 22744634
DOI: 10.1007/s12031-012-9847-9

Genes

NGF
BDNF

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