Article
Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.
The Journal of biological chemistry - 12 Sept 1997
Di Marco A, Gloaguen I, Demartis A, Saggio I, Graziani R, Paonessa G, Laufer R
Abstract excerpt
Ciliary neurotrophic factor (CNTF) drives the sequential assembly of a receptor complex containing the ligand-specific alpha-receptor subunit (CNTFR) and the signal-transducing beta-subunits gp130 and leukemia inhibitory factor receptor-beta (LIFR). CNTFR can function in either membrane-bound or...
Topics
- Antigens, CD
- Biological Assay
- Ciliary Neurotrophic Factor
- Cytokine Receptor gp130
- Dose-Response Relationship, Drug
- Growth Inhibitors
- Humans
- Interleukin-6
- Leukemia Inhibitory Factor
- Leukemia Inhibitory Factor Receptor alpha Subunit
- Lymphokines
- Membrane Glycoproteins
- Membrane Proteins