Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

Abstract excerpt

Proximal signaling events and protein-protein interactions initiated after activation of the c-Ret receptor tyrosine kinase by its ligand, glial cell line-derived neurotrophic factor (GDNF), were investigated in cells carrying native and mutated forms of this receptor. Mutation of Tyr-1062 (Y1062F) in the cytoplasmic tail of c-Ret abolished receptor binding and phosphorylation of the adaptor Shc and eliminated...

Topics

• 3T3 Cells
• Adaptor Proteins, Signal Transducing
• Adaptor Proteins, Vesicular Transport
• Animals
• Binding Sites
• Blotting, Western
• Cell Line
• Cell Survival
• Chromones
• Cytoplasm
• Dose-Response Relationship, Drug