Article
Genetic and epigenetic alteration of the NF2 gene in sporadic meningiomas.
Genes, chromosomes & cancer - 1 Mar 2005
Lomas Jesus, Bello M Josefa, Arjona Dolores, Alonso M Eva, Martinez-Glez Victor, Lopez-Marin Isabel, Amiñoso Cinthia, de Campos Jose M, Isla Alberto, Vaquero Jesus, Rey Juan A
Abstract excerpt
The role of the NF2 gene in the development of meningiomas has recently been documented; inactivating mutations plus allelic loss at 22q, the site of this gene (at 22q12), have been identified in both sporadic and neurofibromatosis type 2-associated tumors. Although epigenetic inactivation through aberrant CpG island methylation of the NF2 5' flanking region has been documented in schwannoma (another...
Topics
- Chromosome Aberrations
- Chromosomes, Human, Pair 22
- CpG Islands
- DNA Methylation
- Genes, Neurofibromatosis 2
- Humans
- Loss of Heterozygosity
- Meningeal Neoplasms
- Meningioma
- Microsatellite Repeats
- Mutation
- Polymorphism, Single-Stranded Conformational