Article
Allelic losses in neurofibromatosis 2-associated meningiomas.
Journal of neuropathology and experimental neurology - 1 Jun 2000
Lamszus K, Vahldiek F, Mautner V F, Schichor C, Tonn J, Stavrou D, Fillbrandt R, Westphal M, Kluwe L
Abstract excerpt
More than 50% of patients with neurofibromatosis 2 (NF2) develop meningiomas. Recently, a higher proliferative activity, more mitotic figures, and greater nuclear pleomorphism have been described for NF2-associated meningiomas compared with sporadic ones. To analyze whether such histological differences could reflect underlying genetic differences, we examined 30 meningiomas from 22 NF2 patients for allelic...
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