Article
Comprehensive genetic and epigenetic analysis of sporadic meningioma for macro-mutations on 22q and micro-mutations within the NF2 locus.
BMC genomics - 12 Jan 2007
Hansson Caisa M, Buckley Patrick G, Grigelioniene Giedre, Piotrowski Arkadiusz, Hellström Anders R, Mantripragada Kiran, Jarbo Caroline, Mathiesen Tiit, Dumanski Jan P
Abstract excerpt
BACKGROUND: Meningiomas are the most common intracranial neoplasias, representing a clinically and histopathologically heterogeneous group of tumors. The neurofibromatosis type 2 (NF2) tumor suppressor is the only gene known to be frequently involved in early development of meningiomas. The objective of this study was to identify genetic and/or epigenetic factors contributing to the development of these tumors. A...
Topics
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 22
- DNA Methylation
- Epigenesis, Genetic
- Exons
- Genes, Neurofibromatosis 2
- Humans
- Meningeal Neoplasms
- Meningioma
- Monosomy
- Mutation
- Nucleic Acid Hybridization