Article
Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma.
The American journal of pathology - 1 Apr 1995
Wellenreuther R, Kraus J A, Lenartz D, Menon A G, Schramm J, Louis D N, Ramesh V, Gusella J F, Wiestler O D, von Deimling A
Abstract excerpt
There is evidence from cytogenetic and loss of heterozygosity studies for the involvement of a tumor suppressor gene on chromosome 22 in the formation of meningiomas. Recently, the NF2 gene, which causes neurofibromatosis type 2 and which is located in the affected region on chromosome 22, has been identified. A previous study on 8 of the 17 exons of the NF2 gene described mutations in 16% of meningiomas. We have...
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