Article
Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.
International journal of molecular medicine - 1 May 1998
Leone P E, Bello M J, Mendiola M, Kusak M E, De Campos J M, Vaquero J, Sarasa J L, Pestana A, Rey J A
Abstract excerpt
Schwannomas are common benign tumours of schwann cell origin, frequently found in patients with neurofibromatosis type 2 (NF2). Inactivation of the NF2 tumour suppressor gene appears to be a molecular event responsible for the development of up to 60% of cases, but no data are available on other superimposed secondary or alternative molecular abnormalities in those schwannomas lacking NF2 gene inactivation. We...
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