Article
Lack of genetic and epigenetic changes in meningiomas without NF2 loss.
The Journal of pathology - 1 Mar 2006
van Tilborg Angela A G, Morolli Bruno, Giphart-Gassler Micheline, de Vries Annie, van Geenen Daniëlle A N, Lurkin Irene, Kros Johan M, Zwarthoff Ellen C
Abstract excerpt
Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumour suppressor gene. The causative gene for the remaining meningiomas is unknown. Previous studies have shown that these tumours have no recurrent karyotypic abnormalities. They differ from their NF2-related counterparts in that they are more often of the meningothelial subtype and are located preferentially in the anterior skull...
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