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Article

Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators.

BMC systems biology - 14 Nov 2015

Padi Megha, Quackenbush John

Abstract excerpt

BACKGROUND: Genome-wide libraries of yeast deletion strains have been used to screen for genes that drive phenotypes such as stress response. A surprising observation emerging from these studies is that the genes with the largest changes in mRNA expression during a state transition are not those that drive that transition. Here, we show that integrating gene expression data with context-independent protein...

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Identifiers

PMID: 26576632
DOI: 10.1186/s12918-015-0228-1
PMCID: PMC4650867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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