Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein complexes are central in the yeast genetic landscape.

PLoS computational biology - 1 Feb 2011

Michaut Magali, Baryshnikova Anastasia, Costanzo Michael, Myers Chad L, Andrews Brenda J, Boone Charles, Bader Gary D

Abstract excerpt

If perturbing two genes together has a stronger or weaker effect than expected, they are said to genetically interact. Genetic interactions are important because they help map gene function, and functionally related genes have similar genetic interaction patterns. Mapping quantitative (positive and negative) genetic interactions on a global scale has recently become possible. This data clearly shows groups of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Models, Biological

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 21390331
DOI: 10.1371/journal.pcbi.1001092
PMCID: PMC3044758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein complexes are central in the yeast genetic landscape.PMID 21390331Read ↗

The genetic landscape of a cell.Semantic proximity Read ↗

Systematic analysis of complex genetic interactions.Semantic proximity Read ↗

A quantitative analysis of monochromaticity in genetic interaction networks.Semantic proximity Read ↗

Multiple genetic interaction experiments provide complementary information useful for gene function prediction.Semantic proximity Read ↗

Conserved rules govern genetic interaction degree across species.Semantic proximity Read ↗

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles.Semantic proximity Read ↗

Defining genetic interaction.Semantic proximity Read ↗

A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.Semantic proximity Read ↗

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read ↗

Quantitative epistasis analysis and pathway inference from genetic interaction data.Semantic proximity Read ↗

Genetic interaction networks: toward an understanding of heritability.Semantic proximity Read ↗

Genetic effects on molecular network states explain complex traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.