Article
Genetic effects on molecular network states explain complex traits.
Molecular systems biology - 8 Aug 2023
Weith Matthias, Großbach Jan, Clement-Ziza Mathieu, Gillet Ludovic, Rodríguez-López María, Marguerat Samuel, Workman Christopher T, Picotti Paola, Bähler Jürg, Aebersold Ruedi, Beyer Andreas
Abstract excerpt
The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but so far, no concept has been established to include the global network state. Here, we show when and how genetic perturbations lead to molecular changes that are confined...
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