Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network.

Abstract excerpt

The vast majority (>95%) of single-gene mutations in yeast affect not only the expression of the mutant gene, but also the expression of many other genes. These data suggest the presence of a previously uncharacterized "gene expression network"--a set of interactions between genes which dictate gene expression in the native cell environment. Here, we quantitatively analyze the gene expression network revealed by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Databases, Genetic