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Article

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2008

Krampert Monika, Heldin Carl-Henrik, Heuchel Rainer L

Abstract excerpt

Platelet-derived growth factor (PDGF) isoforms stimulate cell proliferation, migration and survival. We recently generated mice carrying a gain-of-function mutation within the activation loop of PDGF beta-receptor (PDGFR-beta D849N). Embryonic fibroblasts derived from these mice show elevated basal phosphorylation and altered kinetics for ligand-induced activation of PDGFR-beta, as well as enhanced proliferation...

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Source

Identifiers

PMID: 18762776
DOI: 10.1038/labinvest.2008.81

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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