Article

Overactive PDGFRα and PDGFRβ promote distinct yet overlapping phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving drastic muscle growth

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background: </h4> Fibrosis accumulates in skeletal muscle over time and leads to greater muscle rigidity, stiffness, and increased risk of injuries. However, investigations of experimental models to study the mechanisms through which muscle fibrosis occurs are often confounded by injury or disease. The contribution of platelet-derived growth factor receptors alpha and beta (PDGFRα or PDGFRβ)...

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Literature Corpus work: 182896bf-b98e-5593-a8a7-8b6c3d2fd4c8
DOI: 10.64898/2026.01.02.697406

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