Article
Chimera analysis reveals that fibroblasts and endothelial cells require platelet-derived growth factor receptorbeta expression for participation in reactive connective tissue formation in adults but not during development.
The American journal of pathology - 1 May 1999
Crosby J R, Tappan K A, Seifert R A, Bowen-Pope D F
Abstract excerpt
The hypothesis that platelet-derived growth factor (PDGF) plays an important role in repair of connective tissue has been difficult to test experimentally, in part because the disruption of any of the PDGF ligand and receptor genes is embryonic lethal. We have developed a method that circumvents the embryonic lethality of the PDGF receptor (R)beta-/- genotype and minimizes the tendency of compensatory processes...
Topics
- Animals
- Cell Division
- Chimera
- Connective Tissue
- Embryonic and Fetal Development
- Endothelium, Vascular
- Fibroblasts
- Genotype
- Granulation Tissue
- Leukocyte Count
- Mice
- Mice, Inbred C57BL
- Receptor, Platelet-Derived Growth Factor beta