Article
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2015
Bansal Ankita, Zhu Lihua J, Yen Kelvin, Tissenbaum Heidi A
Abstract excerpt
Aging research has been very successful at identifying signaling pathways and evolutionarily conserved genes that extend lifespan with the assumption that an increase in lifespan will also increase healthspan. However, it is largely unknown whether we are extending the healthy time of life or simply prolonging a period of frailty with increased incidence of age-associated diseases. Here we use Caenorhabditis...
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