Article
T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
Immunity - 1 Dec 2004
Price David A, West Sadie M, Betts Michael R, Ruff Laura E, Brenchley Jason M, Ambrozak David R, Edghill-Smith Yvette, Kuroda Marcelo J, Bogdan Derek, Kunstman Kevin, Letvin Norman L, Franchini Genoveffa, Wolinsky Steven M, Koup Richard A, Douek Daniel C
Abstract excerpt
Escape from adaptive T cell immunity through transmutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T cell receptor (TCR)-antigen interface are unknown. Here, we show that mutational escape is intimately linked to the structural configuration...
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