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Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations.

Aging and disease - 31 Jan 2025

Liang Runyu, Tang Qiang, Chen Jia, Huang Yongyin, Zhu Luwen

Abstract excerpt

Since the association between mitochondria and aging was first identified, significant efforts have been devoted to elucidating the role of mitochondrial DNA mutations in the aging process. Due to their age-dependent accumulation, intrinsically high mutation rates, and defective replication mechanisms, mtDNA mutations have often been regarded as pivotal drivers of aging. This has led to certain intuitive yet...

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PMID: 39908271
DOI: 10.14336/AD.2024.1469
PMCID: PMC12727128

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